The ongoing Phase 2 proof-of-concept clinical trial and the upcoming data release will be critical in evaluating and confirming these potential benefits and therapeutic rationale
Also GLP1RAs have been found to decrease epicardial fat, which may help explain their potential in lowering the risk of atherosclerosis
Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A (2004) Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
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In the AKI subgroup, the mortality rate was 8.8%, while in the non-AKI subgroup, the mortality rate was 0.7% [112]